• 理念
• 最近の主な業績
• 研究支援活動
• 研究員
• センター長の紹介

長野県における小児高度専門医療施設として位置づけられる当院では、高度で専門的な小児医療を支えるための先端的な解析技術の獲得と、その診断・治療への応用が求められています。生命科学研究センターは、その中心的な役割を担うことを目的に設置されました。センターが行う業務を通して、今まで明らかにできなかった疾患や病態の原因を解明できる可能性があります。その結果、治療方針や予後などに関する見通しが立ち、医療、療育に生かすことができます。また、新しい診断方法や治療法の開発につながることが期待されます。
(文部科学省科学研究費助成事業指定研究機関)

理念

1. 将来を担う子どもたちに対する高度で専門的な医療を側面から支援するために遺伝学的解析をはじめとする研究を推進し、臨床と研究の間の橋渡しを行います。
2. 医療との連携のもと、小児疾患を対象とした病態解析および研究から得られた情報を広く社会に向けて発信します。
3. 生命科学の調査、研究の専門家を育成し、啓発普及のため教育研修を行います。

最近の主な業績

1. Prospective cohort study for postnatal cytomegalovirus infection in preterm infants. J Obstet Gynaecol Res. 2023 Mar 8. doi: 10.1111/jog.15628. Online ahead of print. PMID: 36890689
2. Early Phase Increase in Serum TIMP-1 in Patients with Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion. Children (Basel). 2022 Dec 30;10(1):78. doi: 10.3390/children10010078.PMID: 36670630
3. Development and validation of novel automatable assay for cholesterol efflux capacity. Biosci Rep. 2023 Jan 16:BSR20221519. doi: 10.1042/BSR20221519. Online ahead of print. PMID: 36645426
4. Partial Efficacy of Vigabatrin in an Infant with West Syndrome due to Pyruvate Dehydrogenase Complex Deficiency: A Case Report. Pediatr Neurol. 2022 Nov 2;138:98-100. doi: 10.1016/j.pediatrneurol.2022.10.012. Online ahead of print. PMID: 36436329
5. Basophil activation test for allergic and febrile non-haemolytic transfusion reactions among paediatric patients with haematological or oncological disease. Vox Sang. 2022 Oct 12. doi: 10.1111/vox.13365. Online ahead of print.PMID: 36224113
6. Development of Free 25-Hydroxyvitamin D3 Assay Method Using Liquid Chromatography-Tandem Mass Spectrometry. Biosci Rep. 2022 Sep 15:BSR20221326. doi: 10.1042/BSR20221326. Online ahead of print.PMID: 36107130
7. Clinical and molecular features of patients with COL1-related disorders: Implications for the wider spectrum and the risk of vascular complications. Am J Med Genet A. 2022 Sep;188(9):2560-2575. doi: 10.1002/ajmg.a.62887. Epub 2022 Jul 13. PMID: 35822426
8. Detection of Bacillus cereus as a causative agent of emetic food poisoning by an unconventional culture procedure. J Infect Chemother. 2022 Jul 20:S1341-321X(22)00207-0. doi: 10.1016/j.jiac.2022.07.011. Online ahead of print. PMID: 35870790
9. Impact of maternal dyslipidemia on infant neurodevelopment: The Japan Environment and Children’s Study. Brain Dev. 2022 May 25:S0387-7604(22)00083-3. doi: 10.1016/j.braindev.2022.05.002. PMID: 35643833
10. Immature Platelet Fraction and its Kinetics in Neonates. J Pediatr Hematol Oncol. 2022 May 20. doi: 10.1097/MPH.0000000000002487. Online ahead of print.PMID: 35622986
11. Relationship between allergic transfusion reactions and allergic predisposition among pediatric patients with hematological/oncological disease. Transfusion. 2022 Mar 16. doi: 10.1111/trf.16855. Online ahead of print.PMID: 35297063
12. Neuropsychological and neurophysiological features of WAGR syndrome: Detailed comprehensive evaluation of a patient with severe intellectual disability and autism spectrum disorder. Brain Dev. 2022 Mar;44(3):229-233. doi: 10.1016/j.braindev.2021.11.006. Epub 2021 Dec 6.PMID: 34876316
13. High Incidence of Hippocampal Abnormalities in Pediatric Patients with Congenital Cytomegalovirus Infection. Neuropediatrics. 2022 Jan 28. doi: 10.1055/a-1754-1142. Online ahead of print.PMID: 35098496
14. Novel cholesterol efflux assay using immobilized liposome-bound gel beads: Confirmation and improvement for application in clinical laboratory. Ann Clin Biochem. 2021 Nov 4:45632211054406. doi: 10.1177/00045632211054406. Online ahead of print. PMID: 34719976
15. Successful treatment of congenital myasthenic syndrome caused by a novel compound heterozygous variant in RAPSN. Brain Dev. 2021 Sep 23:S0387-7604(21)00160-1. doi: 10.1016/j.braindev.2021.09.001. Online ahead of print. PMID: 34565654
16. Effect of myeloperoxidase oxidation and N-homocysteinylation of high-density lipoprotein on endothelial repair function. Biol Chem. 2021 Aug 25. doi: 10.1515/hsz-2021-0247. Online ahead of print. PMID: 34448387
17. Investigation of patient factors associated with the number of transfusions required during chemotherapy for high-risk neuroblastoma. Vox Sang. 2021 Jul 1. doi: 10.1111/vox.13128. Online ahead of print.PMID: 34197634.
18. Sequential Therapy of Inotuzumab Ozogamicin and Blinatumomab as a Bridge-to Hematopoietic Stem Cell Transplantation in a Pediatric Patient With Primary Refractory Acute Lymphoblastic Leukemia: A Case Report. J Pediatr Hematol Oncol. 2021 May 18. doi: 10.1097/MPH.0000000000002205.
19. Apolipoprotein C-II and C-III preferably transfer to both high-density lipoprotein (HDL)2 and the larger HDL3 from very low-density lipoprotein (VLDL). Biol Chem. 2021 May 26; 402(4):439-449. doi: 10.1515/hsz-2020-0288.
20. Marked Changes in Serum Amyloid A Distribution and High-Density Lipoprotein Structure during Acute Inflammation. Biomed Res Int. 2021 Jan 27;2021:9241259. doi: 10.1155/2021/9241259.
21. Relationship between allergic sensitisation-associated single-nucleotide polymorphisms and allergic transfusion reactions and febrile non-haemolytic transfusion reactions in paediatric cases. Blood Transfus. 2021 Feb 3. doi: 10.2450/2021.0230-20.
22. Cholesterol transport between red blood cells and lipoproteins contributes to cholesterol metabolism in blood. J Lipid Res. 2020 Dec;61(12):1577-1588. doi: 10.1194/jlr.RA120000635.
23. Highly oxidized low-density lipoprotein does not facilitate platelet aggregation. J Int Med Res. 2020 Oct; 48(10):300060520958960. doi: 10.1177/0300060520958960.
24. Glycation of HDL polymerizes apolipoprotein M and attenuates its capacity to bind to Sphingosine 1-Phosphate. J Atheroscler Thromb. 2020 Oct 1. doi: 10.5551/jat.55699. Online ahead of print.PMID: 32999208
25. Comparison of a novel cholesterol efflux assay using immobilized liposome-bound gel beads with the conventional method. Biosci Rep, 2020 Aug 28; 40 (8):BSR20201495. doi: 10.1042/BSR20201495.
26. A case of pure erythroid leukemia with MYB-GATA1 fusion that developed tumor lysis syndrome with dexamethasone. Pediatr Blood Cancer. 2020 Jul 7:e28285. doi: 10.1002/pbc.28285.
27. Transfusion outcome for volume- and plasma-reduced platelet concentrates for pediatric patients. Transfus Apher Sci. 2020 May 18:102776. doi: 10.1016/j.transci.2020.102776.
28. Prophylactic piperacillin administration in pediatric patients with solid tumors following different intensities of chemotherapy. Pediatr Int. 2019 Dec 17. doi: 10.1111/ped.14103.
29. Analysis of the clinical characteristics of pediatric patients who experience ifosfamide-induced encephalopathy. Pediatr Blood Cancer. 2019 Dec;66(12):e27996. doi: 10.1002/pbc.27996.
30. Analysis of clinical presentations of allergic transfusion reactions and febrile non-haemolytic transfusion reactions in paediatric patients. Vox Sang. 2019 Nov;114(8):826-834. doi: 10.1111/vox.12833.
31. Red blood cells participate in reverse cholesterol transport by mediating cholesterol efflux of high-density lipoprotein and apolipoprotein A-I from THP-1 macrophages. Biol Chem. 2019 Nov 26;400(12):1593-1602. doi: 10.1515/hsz-2019-0244.

研究支援活動

長野県立こども病院は、全職員を対象に臨床医学研究助成制度を設け、厳正なる審査を通過した職員に研究助成金を授与することによって、研究活動を支援しています。
また、2019年4月から信州大学との連携大学院が開講し、複数名の医師、医療技術職員が社会人大学院生として研究を遂行しています。生命科学研究センターはこれらの大学院生を中心とする全職員の研究支援・指導を通じて、研究マインドを備えた次世代小児医療を担う医療人の育成を目指しています。

研究員

研究員名簿

センター長の紹介